The Department of Applied Chemistry has awarded a Master's degree to the graduate student "Raghda Fares Salem
The Department of Applied Chemistry has awarded a Master's degree to the graduate student "Raghda Fares Salem" for her thesis titled:
“Assessment of B-type natriuretic peptide, Wingless type 5 A in and other markers in Iraqi Patients with Heart Failure “
The thesis defense was held in the late Professor Dr. Abdul-Muttalib Ibrahim Al-Sheikh Hall in the department building. The examination committee was composed of:
- Professor Dr. Abdul-Nasser Mohammed Abdullah, Department of Applied Sciences/Applied Chemistry, Chair
- Assistant Professor Dr. Raed Jassim Mohammed, Al-Nahrain University/College of Medicine/Department of Chemistry and Biochemistry, Member
- Assistant Professor Dr. Mohammed Shaamil Ali, Department of Applied Sciences/Applied Chemistry, Member
- Assistant Professor Dr. Wafaa Raaji Mohammed, Department of Applied Sciences/Applied Chemistry, Member and Supervisor
- Assistant Professor Dr. Mohammed Abdul-Jabbar Hammoudi, Al-Nahrain University/College of Medicine/Department of Chemistry and Biochemistry, Member and Supervisor
The aim of this study was to measure the levels of B-type Natriuretic Peptide (BNP), Wingless Type 5a (Wnt5a), and other indicators as diagnostic markers for heart failure patients. Additionally, the study sought to explore potential correlations between these biomarkers and other parameters such as random blood sugar, urea, creatinine, potassium, calcium, lipids, CK, CRP, troponin, LDH, and AST, which are relevant to the disease. The study also aimed to assess cardiovascular disease prediction in patients with chronic kidney disease. The research was conducted at Sheikh Zayed Hospital from December 2022 to April 2023. The study included 100 cases (50 male and 50 female), aged 40-65 years. Of these, 50 patients had heart failure (25 male and 25 female) and 50 had both heart failure and kidney dysfunction (25 male and 25 female), all diagnosed by a cardiology consultant. The study found a significant increase in BNP, Wnt5a, random blood sugar, CRP, troponin, urea, creatinine, uric acid, cholesterol, triglycerides, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and CK, as well as a decrease in uPa, potassium, calcium, HDL, and AST in patients with heart failure and kidney disease. Results indicated that some of these markers could be used as diagnostic indicators for heart failure. A significant positive correlation was found between BNP and Wnt5a (r = 0.35, p ≤ 0.001), and a significant positive correlation was observed between random blood sugar and BNP (r = 0.56, p < 0.001), as well as random blood sugar and Wnt5a (r = 0.37, p < 0.001). A significant positive correlation was also found between CRP and BNP (r = 0.52, p < 0.001) and between CRP and Wnt5a (r = 0.45, p < 0.001). Additionally, there was a significant positive correlation between kidney function and both BNP and Wnt5a. The study highlighted a strong positive relationship between cholesterol, triglycerides, and VLDL with BNP and Wnt5a, as well as a strong positive correlation between CK and LDH with BNP and Wnt5a. Elevated BNP and Wnt5a levels in patients with heart disease were identified as early diagnostic markers for heart failure. Increased levels of random blood sugar, CRP, troponin, cholesterol, triglycerides, LDL, VLDL, CK, and LDH were found in heart failure patients. The study results suggested that low levels of uPa, potassium, calcium, HDL, and AST are associated with heart failure, potentially increasing the risk of heart failure as these parameters play crucial roles in heart disease.
